Development of a stress response therapy targeting aggressive prostate cancer
نویسندگان
چکیده
منابع مشابه
Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer
Radiation therapy (RT) is one of the mainstay treatments for prostate cancer (PCa). The potentially curative approaches can provide satisfactory results for many patients with non-metastatic PCa; however, a considerable number of individuals may present disease recurrence and die from the disease. Exploiting the rich molecular biology of PCa will provide insights into how the most resistant tum...
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E arlier epidemiological studies identified diet as a primary environmental factor that determines substantial differences in prostate cancer incidence and mortality between East Asian and West European societies. New data from experiments performed in tissue culture and with animal models as well as epidemiological studies suggest that psychoemotional stress could be a second environmental com...
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Most prostate cancers (PCas) are classified as acinar type (conventional) adenocarcinoma which are composed of tumor cells with luminal differentiation including the expression of androgen receptor (AR) and prostate-specific antigen (PSA). There are also scattered neuroendocrine (NE) cells in every case of adenocarcinoma. The NE cells are quiesecent, do not express AR or PSA, and their function...
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The human cellular genome is under constant stress from extrinsic and intrinsic factors, which can lead to DNA damage and defective replication. In normal cells, DNA damage response (DDR) mediated by various checkpoints will either activate the DNA repair system or induce cellular apoptosis/senescence, therefore maintaining overall genomic integrity. Cancer cells, however, due to constitutive g...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2018
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aar2036